We evaluated the potential of volumetric ADC histogram measurements (vADC) obtained pre- and 6 weeks (6w) post-treatment for prediction of HCC response to 90Yttrium radioembolization (RE). 22 patients underwent MRI at baseline and 6w after RE using a routine liver MRI protocol including DWI. Tumor response was assessed by mRECIST at 6 months post treatment. vADC mean, median and mode obtained at 6w post-treatment were significantly different between patients with partial/complete response vs. those with stable/progressive disease, and were a significant predictor of complete tumor response at 6 months, with vADC mode performing best. Pre-treatment vADC did not have any predictive value for response.