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Abstract #4359

Evaluation of HCC Response to Loco-regional Therapy: Validation of Response Criteria with MRI using Explant as a Reference

Sonja Gordic1,2, Idoia Corcuera-Solano3, Ashley Stueck4, Pamela Argiriadi3, Preethi Guniganti3, Michael King3, Edward Kim3, Swan Thung4, and Bachir Taouli1,3

1Translational and Molecular Imaging Institute, New York, NY, United States, 2Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland, 3Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

We assessed the performance of various imaging response criteria for the prediction of complete pathologic necrosis (CPN) of hepatocellular carcinoma post locoregional therapy on liver explant. Patients who underwent liver transplantation after locoregional therapy were included in this retrospective study. All patients underwent MRI using routine liver protocol within 90 days of liver transplant. RECIST, mRECIST, EASL, percentage of necrosis on subtraction images, and DWI (signal intensity and ADC) were assessed. CPN was retrospectively assessed in all tumors at histopathology. mRECIST, EASL, percentage of necrosis and signal intensity on DWI were all significant predictors of CPN while RECIST and ADC criteria were not.

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