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Abstract #4364

Evaluation of tumor oxygenation following radiation and PS-targeting antibody therapy in an orthotopic lung cancer model

Heling Zhou1, Olivier Belzile2, Zhang Zhang3, Debabrata Saha3, Jo Wagner1, Brock Sishc3, Strahinja Stojadinovic3, Rolf Brekken2,4, and Ralph P Mason1

1Radiology, Univ Texas Southwestern Medical Center, Dallas, TX, United States, 2Hamon Center for Therapeutic Oncology Research, Univ Texas Southwestern Medical Center, Dallas, TX, United States, 3Radiation Oncology, Univ Texas Southwestern Medical Center, Dallas, TX, United States, 4Surgery, Univ Texas Southwestern Medical Center, Dallas, TX, United States

Combining phosphatidylserine (PS)-targeting monoclonal antibodies with radiation therapy can potentially enhance treatment efficacy. Oxygenation is important in radiation therapy response and could influence future treatment design. Oxygen enhanced MRI was used to examine changes in oxygenation in orthotopic lung tumors in rats treated by radiation or radiation plus a PS-targeting antibody. Orthotopic tumors were well oxygenated and responsive to oxygen breathing challenges before and after treatment. Combination therapy appeared to be more effective in tumor control than radiation alone.

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