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Abstract #4365

Multiparametric MRI assessment of tumor physiological changes during hypofractionated SABR

Heling Zhou1, Zhang Zhang2, Rebecca Denney1, Jessica S Williams3, Jeni Gerberich1, Strahinja Stojadinovic2, Debabrata Saha2, John M Shelton3, and Ralph P Mason1

1Radiology, Univ Texas Southwestern Medical Center, Dallas, TX, United States, 2Radiation Oncology, Univ Texas Southwestern Medical Center, Dallas, TX, United States, 3Internal Medicine, Univ Texas Southwestern Medical Center, Dallas, TX, United States

Hypofractionated stereotactic body radiation therapy, a new radiation treatment scheme, may be particularly susceptible to tumor hypoxia. We applied oxygen enhanced MRI together with DCE MRI to observe tumor physiological changes induced by a radiation fraction in a human lung cancer xenograft rat model. This study showed reduced vascular oxygenation 24 hours after the first fraction of 12 Gy, as indicated by the significant decrease in T2* compared to baseline, but no significant response in dynamic contrast enhanced MRI. DCE parametric maps revealed a multinodular structure in the tumor as confirmed by histology.

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