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Abstract #4389

Discriminatory ability of MRSI and DW-MRI in prostatic diseases in biopsy naïve men with PSA 4-10 ng/ml

Durgesh Kumar Dwivedi1,2, Rajeev Kumar3, Alok Kumar Dwivedi4, Girdhar S. Bora3, Sanjay Thulkar5, Sanjay Sharma5, Siddhartha Datta Gupta6, and Naranamangalam R. Jagannathan1

1Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India, 2Department of Radiodiagnosis, King George's Medical University, Lucknow, India, 3Department of Urology, All India Institute of Medical Sciences, New Delhi, Delhi, India, 4Division of Biostatistics and Epidemiology, Department of Biomedical Sciences, Texas Tech University Health Sciences Center, El Paso, Texas, TX, United States, 5Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, New Delhi, India, 6Department of Pathology, All India Institute of Medical Sciences, New Delhi, New Delhi, India

Multivariate approach of including different MR parameters offer a holistic view of entire data, which could provide better approach in differentiating various prostatic diseases. This approach may help in reducing the burden of unnecessary biopsy in men with PSA 4-10 ng/ml. we evaluated discriminatory ability of MRSI and DW-MRI in prostatic diseases in biopsy naïve men with PSA 4-10 ng/ml. The combined model (PSA + ADC + metabolite ratio) showed highest discriminatory ability in various prostatic diseases with AUC of 89% in men with clinically challenging group of PSA.

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Abstract