Tumours in Hesx1Cre/+;Ctnnb1lox(ex3)/+ mice resemble human adamantinomatous craniopharyngioma (ACP) molecularly and histologically. MRI and ex vivo micro-CT were used to assess the radiology of this model for the first time. Early enlargement and heterogeneity of Hesx1Cre/+;Ctnnb1lox(ex3)/+ pituitaries was evident; enlargement of a solid tumour, and development of cysts and haemorrhage subsequently occurred. Solid components showed heterogeneous T1-weighted signal enhancement following Gd-DTPA administration, and in some animals cysts were hyperintense on FLAIR and T1-weighted images, both emulating clinical observations. Cyst calcification was not observed by micro-CT but we show that Hesx1Cre/+;Ctnnb1lox(ex3)/+ tumours faithfully recapitulate the MRI radiology of the human disease.