Multiparametric MRI is the standard for the detection and characterization of prostate cancer. In this study we compared the diagnostic value of clinically used DW-MRI and DCE-MRI in a transgenic mouse model of prostate cancer (TRAMP). Additionally, we investigated the potential utility of SSC-MRI using a USPIOs contrast agent for prostate cancer detection. The results of this study confirm the utility of DW-MRI and the potential value of DCE-MRI in early-stage detection and monitoring of prostate cancer. SSC-MRI appears to be less useful for this task in the TRAMP model, but further analysis is required to draw a clear conclusion.