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Abstract #4492

Application of Cardio-Respiratory Gated High Resolution 3D Balanced SSFP to Liver Tumour Imaging in the Mouse

Ana L Gomes1, Paul Kinchesh1, Stuart Gilchrist1, Alex Gordon-Weeks1, Ruth J Muschel1, and Sean C Smart1

1CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom

Prospective gating and automatic reacquisition of data corrupted by respiration motion were implemented in 3D balanced steady-state free precession (bSSFP) to provide contrast that enables unambiguous detection of liver tumours in the whole mouse liver with 200 ┬Ám isotropic resolution and in scan times that are routinely less than 7 minutes. The method was used for orthotopic tumour burden quantification in 8 female C57BL/6 mice at days 7, 9, and 11 post intra-hepatic injection of MC38-GFP cells, and enabled measurement of tumour volumes less than 1 mm3.

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