The present work seeks to explore the accuracy and precision of proton MR oximetry imaging (MOXI) in silico. MOXI technique relies on the separation of oxygen sensitive T2Blood from the bi-exponential nature of overall T2 decay. The bi-exponential T2 decay models with Rician distribution noise were numerically generated, simulating the preclinical prostate tumor model experiments. The present in silico study showed the feasibility of the proton based MOXI technique. However, the results suggest that the MOXI technique may lack the accuracy and precision of measuring short T2Blood (< 30 ms), which is essential to measure hypoxia in a tumor.