Characterization of intratumoral heterogeneity is crucial for the accuracy and specificity of MRI evaluation of cancer. BOLD MRI, which is widely used for investigating tumor oxygenation, is sensitive to the structure and function of tumor vasculature. We present a method, based on BOLD effect (R2* dynamics), for differentiating subregions in rat 13762NF tumors that show different degrees of sensitivity with respect to hyperoxic and hypoxic gas breathing challenges. We further show the potential connection between the classified heterogeneity and tumor growth.
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