We show the utility of a non-nutritive sweetener, sucralose, as a contrast agent in cancer MRI studies by exploiting its chemical exchange saturation transfer (sucCEST) property. The extracellular-extravascular accumulation of sucralose in a glioma model provides localized, temporal changes in the CEST contrast, corroborating the gadolinium-enhanced MRI. These findings illustrate the potential of sucCEST for diagnosis and monitoring of the therapeutic response of cancers, including gliomas in preclinical studies.
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