vascular permeability and hemodynamic alteration in a broad normal appearing
brain tissue in response to the transplantation of hMSCs after TBI were longitudinally
investigated up to 3-months post-injury. Our data reveal the evidence that a quicker recovery
of vascular integrity, as a result of cell transplantation, is associated with a higher
level of cerebral perfusion, and acute cell administration after TBI
significantly promotes these global therapeutic effects. The findings of the current study indicate that BBB reconstitution plays an essential role in CBF restoration in the injured
brain, which in turn, contributes to the improvement of functional outcome.