The current study investigated the feasibility of using glucoCEST technique, without delivering exogenous glucose as contrast agent, to measure the endogenous glucose content in brain by optimizing the saturation power and duration. The glucoCEST data were compared to the gold-standard 14C-2-deoxyglucose autoradiography for testing the sensitivity and specificity in the detection of hypometabolic syndrome in a rat model of diffuse traumatic brain injury (TBI). The glucoCEST showed comparable results to the 2DG-autoradiography showing glucose uptake largely decreased after TBI. Our findings suggest that glucoCEST could be a robust and reliable imaging modality capable of monitoring glucose metabolism non-invasively.
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