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Abstract #4551

Brain parenchyma pulsatility assessed with ferumoxytol enhanced T2* MRI.

Leonardo A Rivera Rivera1, Patrick Turski1,2, Oliver Wieben1,2, Scott B Reeder2, Tilman Schubert 2, and Kevin M Johnson1

1Dept. of Medical Physics, University of Wisconsin-Madison, MADISON, WI, United States, 2Dept. of Radiology, University of Wisconsin-Madison, Madison, WI, United States

Pulsatility differences in large intracranial arteries and veins have been observed in patients with dementia using 4D flow MRI. How microvascular pulsatility is affected, however, is unclear. Non-invasive methods to monitor capillary pulsatility are still lacking. In this work, we present a method to assess brain parenchyma microvascular pulsatility using T2* signal changes over the cardiac cycle using ferumoxytol enhanced MRI. Significant differences in PI of the cortical gray matter were found when compared to white matter PI values. This method to assess microvascular blood volume pulsatility over the cardiac cycle might serve as a marker to study capillary pulsatility.

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