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Abstract #4555

Ex-vivo Quantitative Susceptibility Mapping of Human Brain Hemispheres

Arnold M. Evia1, Aikaterini Kotrotsou1, Robert J. Dawe1,2,3, Sue E. Leurgans2,4, Julie A. Schneider2,4,5, David A. Bennett2,4, and Konstantinos Arfanakis1,2,3

1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States, 3Department of Diagnostic Radiology, Rush University Medical Center, Chicago, IL, United States, 4Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States, 5Department of Pathology, Rush University Medical Center, Chicago, IL, United States

In order to establish the role of quantitative susceptibility mapping (QSM) as a diagnostic tool in aging, it is essential to combine QSM with direct assessments of age-related brain pathologies on the same individuals. Using ex-vivo QSM for this purpose may be more advantageous than in-vivo QSM, since ex-vivo QSM assesses the brain in the same condition as histology, and allows imaging of older adults independent of frailty level. However, being able to translate ex-vivo QSM findings to in-vivo is crucial. Therefore, our goal was to investigate the effects of death and fixation on brain QSM data collected ex-vivo.

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