Abstract #4571

4D Flow assessment of ophthalmic artery flow in patients with atherosclerotic internal carotid artery stenotic disease

Tetsuro Sekine¹, Ryo Takagi¹, Yasuo Amano^1,2, Yasuo Murai³, Yoshimitsu Fukushima¹, Erika Orita¹, Takahiro Andoh¹, Yoshio Matsumura³, and Shin-ichiro Kumita¹

¹Radiology, Nippon Medical School, Tokyo, Japan, ²Radiology, Nihon University School of Medicine, Tokyo, Japan, ³Neurosurgery, Nippon Medical School, Tokyo, Japan

We performed 4D Flow MRI assessment of the ophthalmic artery (OphA) flow in patients with internal carotid artery stenosis (ICS). Twenty-one consecutive patients with unilateral ICS were recruited. 4D Flow MRI and acetazolamide-stress brain perfusion SPECT were performed. The flow direction on the affected-side OphA was categorized into native flow and non-native flow based on 4D Flow MRI. In the affected-side MCA territory, the ratio of rest cerebral blood flow to normal control (RCBF_MCA) and cerebral vascular reserve (CVR_MCA) were calculated from SPECT dataset. Eleven patients had native OphA flow and the remaining 10 had non-native OphA flow. RCBF_MCA and CVR_MCA were significantly lower in non-native flow group (84.9±18.9% vs. 69.8±7.3%, p<0.05; 36.4±20.6% vs. 17.0±15.0%, p<0.05). Four patients in the non-native flow group and none in the native flow group were confirmed as high-risk (Sensitivity/Specificity, 1.00/0.65). The 6 min-standard 4D Flow MRI assessment of OphA in patients with ICS can predict intracranial hemodynamic impairment.

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