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Abstract #4588

Neural correlates of cognitive load on working memory in organic-solvent exposed brain using fMRI

Kyung Eun Jang1, Jeehye Seo2, Hyejeong Choi1, Hyunsil Cha1, Eunji Kim1, Moojin Yang1, Jiung Yang1,3, Huijin Song2, and Yongmin Chang1,4

1Medical & Biological Engineering, Kyungpook National University, Daegu, Korea, Republic of, 2Institute of Biomedical Engineering Research, Kyungpook National University, Daegu, Korea, Republic of, 3Daegu Kyungpook Medical Innovation Foundation, Daegu, Korea, Republic of, 4Radiology and Molecular Medicine, College of Medicine, Kyungpook National University, Daegu, Korea, Republic of

Several neuroimaging studies demonstrated that solvent-exposed subjects showed significantly poor performance on the working memory task than did controls [1,2]. However, no investigations have examined how solvent-exposed subjects are influenced by the cognitive load of a working memory task. Therefore, we performed N-back tasks with different cognitive demands using fMRI to investigate the neural basis for possible association between working memory load and memory deficit in the subjects with neurotoxicant solvent exposure. We found a positive correlation between response time of the 1-back task and percent BOLD signal changes in the left inferior parietal cortex, but a positive correlation was not founded of the 2-back task.

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