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Abstract #4598

Hope and the brain: trait hope mediates the protective role of the medial orbitofrontal cortex spontaneous activity against anxiety

Xin Xu1,2, Song Wang1, and Qiyong Gong1

1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, People's Republic of China, 2Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, People's Republic of China

As a personality trait, hope refers to the motivational tendency for initiating actions and generating routes to achieving goals and plays a protective role in anxiety. Here, we investigated the neural basis of hope in 231 adolescents using resting-state functional magnetic resonance imaging (RS-fMRI). We found that trait hope was negatively associated with the spontaneous activity in the bilateral medial orbitofrontal cortex (mOFC). Further mediation analyses revealed that trait hope mediated the relationship between the mOFC activity and trait anxiety. Taken Together, our findings might provide the initial evidence for the brain-personality mechanisms protecting against anxiety.

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