Abstract #4654

Implications of Obstructive Sleep Apnea on Global Cerebral Metabolic Rate of Oxygen

Ana E Rodríguez-Soto¹, Yulin Chang¹, Wen Cao¹, Zachary B Rodgers¹, John A Detre², Erin K Englund¹, Sarah Leinwand³, Richard Schwab³, Michael C Langham¹, and Felix W Wehrli¹

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, United States, ³Division of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Obstructive sleep apnea (OSA) is a chronic disorder caused by intermittent obstruction of the upper airways during sleep. Neurocognitive deficits in this population have previously been associated with altered brain metabolism. In fact, a recent pilot study suggests that global cerebral metabolic rate of oxygen (CMRO₂) may be a potential marker of oxygen metabolic dysfunction in this population. Here, we present preliminary results from an ongoing study designed to quantify CMRO₂ in subjects with OSA and matched controls. Initial results suggest that apneics have overall lower baseline CMRO₂ and increased response to volitional apnea, a paradigm to mimic spontaneous apneas.

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