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Abstract #4722

Triple Magnetic Resonance Angiography (triple-MRA) for planning of Gamma Knife Radiosurgery of brain arteriovenous malformations

Alvaro Rojas Villabona1,2, Magdalena Sokolska3,4, Enrico De Vita4, Mary Murphy2, Thomas Solbach5, Joan Grieve2, Prem Rangi5, Yuriko Suzuki6, Matthias JP Van Osch6, David Atkinson7, Emma Biondetti3, Karin Shmueli3, Xavier Golay4, Ian Paddick1, Neil Kitchen2, and Hans Rolf J├Ąger4,5

1The Gamma Knife Centre at Queen Square, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 2Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 3Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 4Academic Neuroradiological Unit, Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom, 5The Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 6C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 7Centre for Medical Imaging, University College London, London, United Kingdom

This study investigates whether a combination of three MRA techniques, referred to as triple-MRA, could be used as an alternative to DSA for visualisation and delineation of brain AVMs for GKR targeting. The AVMs of 13 patients undergoing GKR were delineated using triple-MRA and the resultant target volumes were compared to the radiosurgical targets generated by the neurosurgical team using DSA and volumetric contrast T1/T2 imaging. Target volumes obtained using triple-MRA are comparable to target volumes obtained with DSA and used for delivery of GKR. In conclusion, triple-MRA is a robust method for non-invasive identification and delineation of brain AVMs.

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