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Abstract #4733

Inversion Recovery Ultrashort Echo Time Imaging of Short T2 Tissue Components in Ovine Brain: A Sequential D2O Exchange Study

Shu-Juan Fan1, Yajun Ma1, Graeme M. Bydder1, and Jiang Du1

1Dept. of Radiology, University of California, San Diego, San Diego, CA, United States

Myelin produces ultrashort-lived MRI signals, and cannot be directly imaged using conventional MRI sequences that typically have TEs of several milliseconds or longer. This study explored the potential of inversion recovery ultrashort echo time (IR-UTE) sequences in direct myelin imaging in an ovine brain D2O exchange model. The IR-UTE signals survived D2O exchange. Myelin T2* was measured to be 200-300 ┬Ás both before and after exchange. These results support myelin to be the major source of the ultrashort T2* signals seen on IR-UTE images, and IR-UTE sequence as a tool for assessing myelin loss in multiple sclerosis and other diseases.

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