Abstract #4745

Using Hyperpolarized 129Xe in Human Participants to Perform Functional Magnetic Resonance Imaging (fMRI)

Francis Hane¹, Tao Li¹, Jane M Lawrence-Dewar², Ayman Hassan³, Karl Granberg³, Raiili Pellizzari¹, Jennifer Anne Plata⁴, and Mitchell Albert^1,5

¹Lakehead University, Thunder Bay, ON, Canada, ²Thunder Bay Regional Research Institute, Thunder Bay, ON, Canada, ³Thunder Bay Regional Health Sciences Centre, ⁴Lakehead University, ⁵Northern Ontario School of Medicine, ON, Canada

We demonstrate the use of hyperpolarized (HP) 129Xe MRI as a novel fMRI modality. We successfully obtained axial HP Xe fMRI maps from healthy humans throughout the conduct of a 1-back memory task. Our preliminary results suggest that HP 129Xe fMRI may have a sensitivity of up to an order of magnitude more than BOLD fMRI.

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