Abstract #4750

Quantitative T1 mapping and somatotopic organization of the cerebellum at 7T : is there a link?

Yohan Boillat¹, Pierre-Louis Bazin², Rolf Gruetter^1,3,4, and Wietske Van der Zwaag^5,6

¹Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ³Department of Radiology, University of Lausanne, Lausanne, Switzerland, ⁴Department of Radiology, University of Geneva, Geneva, Switzerland, ⁵Biomedical Imaging Research Center, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁶Spinoza Centre for Neuroimaging, Amsterdam, Netherlands

In this study, the spatial relationship between the somatotopy and the pattern of myelination (as measured by quantitative T₁-maps) in the cerebellum was investigated. Subject-specific surfaces were generated on which were mapped T₁ values and somatotopic maps. Consistent somatotopic gradients organized through several lobules were present in the anterior and posterior lobes. Despite being more complex, changes of T₁ values across the cerebellar surface were also observed and showed a similar orientation as the somatotopic organization. This study showed the potential structure-function relationship of the cerebellum observed at macroscale level.

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