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Abstract #4784

Improving the Reproducibility of Quantitative Imaging Metrics for Multicentre Multiparametric Prostate MRI Trials

Edward William Johnston1, Michela Antonelli2, Nikolaos Dikaios1, Sebastien Ourselin2, David Atkinson1, and Shonit Punwani1

1Centre for Medical Imaging, University College London, London, United Kingdom, 2Centre for Medical Image Computing, University College London, London, United Kingdom

Whilst multi-scanner studies provide the most robust evidence for quantitative imaging trials, they tend to be limited by poor reproducibility of scans performed on different scanners. In this study, 14 patients underwent paired multiparametric prostate MRI within 3 months of each other. We found that normalisation of T2 signal to the bladder improved the reproducibility of both peripheral zone and transition zone metrics considerably when compared with the current convention of using obturator internus. Whilst ADC also met sufficient levels of reproducibility, semiquantiative and quantitative DCE analysis and histographic features failed to do so.

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