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Abstract #4791

Ex vivo MRI evaluation of prostate cancer: localization and margin status prediction of prostate cancer in fresh radical prostatectomy specimens

Jan Heidkamp1, Martijn Hoogenboom1, Iringo Kovacs2, Andor Veltien1, Arie Maat2, Michiel Sedelaar3, Christina Hulsbergen-van de Kaa2, and Jurgen F├╝tterer1

1Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, 2Pathology, Radboud university medical center, Nijmegen, Netherlands, 3Urology, Radboud university medical center, Nijmegen, Netherlands

This study investigated the ability of high field ex vivo MRI to localize prostate cancer (PCa) and to predict the margin status in fresh radical prostatectomy (RP) specimens using histology as gold standard. In twelve specimens, ex vivo MRI localized 17 (47%) of 36 PCa lesions confirmed by histological examination. Ex vivo MRI identified none of the 4 histological positive surgical margins (sensitivity 0%) and 9 of the 13 negative margins (specificity 69%). Our results indicate accurate localization of PCa in fresh RP specimens by ex vivo MRI, yet the technique did not perform well in predicting the margin status.

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