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Abstract #4809

Characterization of the placental vascular tree using MRI: an ex-vivo study

Daphna Link1,2, Ariel Many3, Liat Ben Sira4, Shaul Harel1,5, and Dafna Ben Bashat1,2,6

1Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 2Functional Brain Center, The Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 3Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 4Division of Pediatric Radiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 5Pediatric Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 6Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel

Placental vascular dysfunction is a major cause of pregnancy complications, such as intrauterine growth restriction (IUGR). However, current knowledge on human placental vascular architecture is limited. In this study, for the first time, we characterized the structure of the placental vascular system ex-vivo, using MRI. Fifteen normal placentas and one with IUGR were studied using a novel method, and the vascular structure was analyzed with an automatic algorithm. Results provided information regarding: cord insertion location; branching pattern; branching generation; and daughter to mother diameters of normal placentas. Preliminary results from one IUGR placenta suggest significant differences from normal placentas.

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