The depth of myometrial invasion was evaluated in 25 patients with surgically proven endometrial cancer by T2WI, reduced field-of-view DWI (rFOV-DWI) and 3D dynamic contrast-enhanced MRI (DCE-MRI). The depth of myometrial invasion (stage S: <50% vs stage D: ≥50%) on MRI was correlated with surgical pathology results. The staging accuracy was 68% for T2WI, 92% for DCE-MRI, and 96% for rFOV-DWI. Combination of rFOV-DWI reading together with T2WI improved the assessment of myometrial invasion with a diagnostic accuracy of up to 100%. Especially, rFOV-DWI has an advantage in assessing the depth of myometrial invasion in cases with coexisting adenomyosis.