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Abstract #4835

Quantitative BOLD MRI and T1 Mapping in Acute Kidney Injury Patients: A preliminary study

Yingjie Mei1,2, Xiang Xiao3, Zihan Lei4, Jie Feng3, Yuankui Wu3, Ruiying Chen3, Qiangqiang Gang3, Min Liang4, Yikai Xu3, and Yanqiu Feng1

1School of Biomedical Engineering, Guangdong Provincial Key Laborary of Medical Image Processing, Southern Medical University, Guangzhou, People's Republic of China, 2Philips Healthcare, Guangzhou, People's Republic of China, 3Medical Imaging Center, Nanfang Hospital of Southern Medical University, Guangzhou, People's Republic of China, 4Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China

Hypoperfusion and hypoxia are thought to be important factors in the pathogenesis of AKI and in the progression from AKI to chronic kidney disease. Previous studies have demonstrated the correlation between MR relaxation time (T1 and T2*) and tissue oxygenation. The result of this preliminary study suggests BOLD and T1 mapping are potential to diagnose AKI at early stage and predict the progression of AKI non-invasively.

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