Staging of liver fibrosis is of great clinical value, because early stage fibrosis is reversible under proper treatment. Liver biopsy, which is currently the golden standard for fibrosis staging, has many limitations. In this study, we evaluated non-invasive IVIM diffusion imaging technique on rabbit liver fibrosis models. As a result, IVIM parameters show significant difference between normal, early and advanced fibrosis liver models. Our study suggests that IVIM parameters have potential to become the biomarker for liver fibrosis staging.
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