Abstract #4878

TWO-DIMENSIONAL PHASE-CONRAST MAGNETIC RESONANCE IMAGING AS TOOL TO DETERMINE HEPATIC HEMODYNAMICS IN RATS WITH A HEALTHY, FIBROTIC OR CIRRHOTIC LIVER

Denise Schaffner^1,2,3, Dominik von Elverfeldt⁴, Peter Deibert^1,2, Irmgard Merfort³, Adhara Lazaro^1,2, Lisa Lutz^2,5, Manfred W. Baumstark^1,2, Wolfgang Kreisel², and Wilfried Reichardt^4,6,7

¹Institute for Exercise- und Occupational Medicine, Center for Medicine, Medical Center - University of Freiburg, Freiburg, Germany, ²Faculty of Medicine, University of Freiburg, Freiburg, Germany, ³Department of Pharmaceutical Biology and Biotechnology, University of Freiburg, Freiburg, Germany, ⁴Department of Radiology Medical Physics, Medical Center – University of Freiburg, Freiburg, Germany, ⁵Institute of Clinical Pathology, Medical Center – University of Freiburg, Freiburg, Germany, ⁶German Cancer Consortium (DKTK), Heidelberg, Germany, ⁷German Cancer Research Centre (DKFZ), Heidelberg

In this work we wanted to test a Magnetic Resonance (MR) scanning protocol as a non-invasive tool to determine hepatic hemodynamics and to assess the liver fibrosis degree in an animal model of liver fibrosis and cirrhosis. MR rat liver images provided a good discrimination of healthy from diseased liver, but for the assessment of liver fibrosis degree histology is indispensable. The results show that portal and aortal flow patterns for a cardiac cycle could be measured with high reliability in Conclusion, this MR scanning protocol presents a reliable non-invasive tool to determine hepatic hemodynamics in healthy and diseased rats

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