HCM is the most common inherited heart disease. The two most frequently seen mutated genes are MYH7 and MYBPC3 which account for nearly 80% of familiar HCM. In this study we hypothesized that these gene variants will affect both LV and RV function. By in-vivo CMR we detected LV hypertrophy in a mouse strain DBA/2J bearing the two gene variants. Interestingly there is no defected LV function found but changes in RV function as both male and female DBA/2J mice had declined RVEF. Our results provide new insights into the correlation of genetic alteration and HCM phenotype.