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Abstract #4888

Histological validation of loading lag of heart iron with respect to liver iron in a rabbit model

xiaodong chen1,2,3, Zipan Chen4, Heng Lv5, Ziliang Cheng6, Qihua Yang6, Zuoquan Zhang7, Zebin Luo1, Jiaji Mao6, Queenie Chan8, Yingjie Mei9, Jingwen Huang6, Wubiao Chen1, Biling Liang6, and Hua Guo10

1Affiliated hospital of Guangdong Medical College, Zhanjiang, People's Republic of China, 2Sun Yat-Sen Memorial Hospital, Guangzhou, People's Republic of China, 3Tsinghua University, Beijing, People's Republic of China, 4Shiyan People’s Hospital, 5Peking University Shenzhen Hospital, 6Sun Yat-Sen Memorial Hospital, 7The Fifth Affiliated Hospital of Sun Yat-Sen University, 8Philips Healthcare, Hong Kong, 9Philips Healthcare, Guangzhou, 10Tsinghua University

Whether there exists a lag in the iron loading between liver and heart in transfusion dependent patients has clinical significance in prevention and treatment of heart iron overload. We performed this study to verify this time lag on a rabbit model. The result shows that the iron loading, measured with pathology, MRI and atomic absorption spectrophotometer, was much faster and heavier in the liver than that in the heart. Therefore, there existed a time lag between heart and liver iron overload on the rabbit model. This may lead to improved clinical guidelines for cardioprotection.

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