Localized spectroscopy of hyperpolarized xenon-129 dissolved in the human head with a dedicated receiver array

This study investigates the spectral signal of hyperpolarized ¹²⁹Xe dissolved in the human head in vivo using a dedicated radiofrequency receiver coil array. With a 2.5-fold higher signal to noise ratio of the array compared to a conventional transmit-receive radiofrequency coil, we detected 8 spectral peaks compared to 5 peaks reported in an earlier study. From this, we postulate an individual assignment of spectral peaks for hyperpolarized ¹²⁹Xe dissolved in white matter and soft cartilaginous tissue, which were previously undistinguishable.