IVIM is a research and clinical focus in recent years. Whether its perfusion-related parameters are correlated with those obtained from DCE is still under debate. So the purpose is to investigate their correlation by performing both IVIM and DCE on 31 malignant and 35 benign lesions from 59 patients. Their diagnostic performance and correlation were investigated. No strong correlation was found between them, although their diagnostic performance is similar in terms of perfusion parameters. So IVIM is useful in lesion differentiation and potentially comparable with DCE-derived perfusion-related parameters. IVIM-derived perfusion-related parameters are probably a new entity of microcirculation parameters.