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Abstract #4933

Comparison of Breast Pharmacokinetic Parameters in Fat-Water and Water Only Images

Philip K. Lee1, Brian A. Hargreaves2, Bruce L. Daniel2, and Subashini Srinivasan2

1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, CA, United States

Pharmacokinetic parameters such as Ktrans, kep and ve can be estimated from contrast enhanced breast MRI using Tofts model. Previous simulation has shown that Ktrans has a maximum bias of 82% at 5s temporal resolutions in the presence of fat. In this work, we have compared the PK parameters estimated from in-phase fat-water, and water-only images in 7 malignant and 4 benign lesions. The presence of fat introduced biases in Ktrans and kep respectively of –0.02 min-1 and 0.01 min-1 in malignant lesions and –0.001 min-1 and –0.003 min-1 in benign lesions, but did not affect the classification of lesions.

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