The individual and combined effects of correction for susceptibility-induced distortion, distortion due to eddy currents, and bias from gradient non-linearity on breast DTI metrics were evaluated. Using an ice-water phantom we found that the correction of gradient nonlinearity resulted in strong bias reduction, while the distortion correction provided further reduction of bias and variance. The effects of these corrections were quantified in 12 subjects with malignant breast tumors and found to parallel the effects measured in the phantom.
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