Abstract #4950

Developing pre-biopsy multiparameteric MRI based risk calculator for predicting prostate cancer in men with PSA 4-10 ng/ml

Durgesh Kumar Dwivedi^1,2, Rajeev Kumar³, Alok Kumar Dwivedi⁴, Girdhar S. Bora³, Sanjay Thulkar⁵, Sanjay Sharma⁵, Siddhartha Datta Gupta⁶, and Naranamangalam R. Jagannathan¹

¹Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India, ²Department of Radiodiagnosis, King George's Medical University, Lucknow, India, ³Department of Urology, All India Institute of Medical Sciences, New Delhi, Delhi, India, ⁴Division of Biostatistics and Epidemiology, Department of Biomedical Sciences, Texas Tech University Health Sciences Center, El Paso, Texas, TX, United States, ⁵Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, New Delhi, India, ⁶Department of Pathology, All India Institute of Medical Sciences, New Delhi, New Delhi, India

Risk calculators have traditionally utilized PSA values in addition to the clinical variables to predict risk assessment of prostate cancer (PCa). For the first time, we aimed to develop pre-biopsy mpMRI based simple risk score (RS) and a predictive model in predicting the risk of PCa in men with clinically challenging value of PSA (4-10 ng/ml) if a TRUS-guided biopsy is performed. The predictive model and developed simplistic 6-point mpMRI score based risk calculator in this study could be routinely used in predicting PCa in clinical management for men with PSA 4-10 ng/ml.

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