Abstract #4998

Validity of skeletal muscle fiber type distinguished using q-space imaging

Junichi Hata^1,2,3, Kanehiro Fujiyoshi², Osahiko Tsuji², Yuji Komaki^2,3, Keigo Hikishima⁴, Masaya Nakamura², and Hideyuki Okano^1,2

¹RIKEN Brain Science Institute, Saitama, Japan, ²Department of Physiology, Keio University School of Medicine, Tokyo, Japan, ³Central Institute for Experimental Animals, Kanagawa, Japan, ⁴Okinawa Institute of Science and Technology, Okinawa, Japan

We developed a technology that the muscle composition ratio can be non-invasively visualize at q-space imaging. And, these MR image confirmed validation by comparison to the skeletal muscle histology. We scanned diffusion data using 7T MRI scanner and performed analysis to calculate QSI index. The mice lower leg was stained by several solutions to enable muscle typing. As a result, the cell size by sections showing the correlation between the QSI indices. Moreover, the visualization in a staining compared, it is possible to obtain the same image. We confirmed validation by comparing the stained image to QSI.

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