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Abstract #5014

Bi-exponential  T2* mapping of peripheral nerve from in-vivo human scans with a 3D UTE cones sequence.

Daehyun Yoon1 and Brian Hargreaves1

1Department of Radiology, Stanford university, Palo Alto, CA, United States

Previous studies with nerve samples have demonstrated the existence of multiple signal components with different T2 or T2* relaxation times in peripheral nerves. The short- T2* signal component has received significant research attention, based on its correlation with myelin health of nerve fiber in many neurological diseases. However, little research has been conducted with in vivo human scans to separate the short-T2* component and the long-T2* component in peripheral nerves. Using a 3D ultra-short echo time (UTE) cones sequence, we demonstrate the feasibility of capturing and separating both bi-exponential T2* signal components from in vivo human nerve scans

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