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Abstract #5040

Insights from a combined study: Linking two modalities – total water content distribution and isotropic water fraction.

Zaheer Abbas1,2, Farida Grinberg1,2, Ezequiel Farrher1, Krzysztof Dzieciol1, Elene Iordanishvili1, and Nadim Jon Shah1,2

1Medical Imaging Physics, Institute of Neuroscience and Medicine, Juelich, Germany, 2Faculty of Medicine, RWTH Aachen, JARA, Aachen, Germany

Two methods – distributions of total free water (FW) content and unrestricted, isotropic water fraction (IWF) were studied in order to establish a possible link between them. MRI protocols were set in order to obtain quantitative FW maps as well as IWF distributions, based on a free water elimination DTI method. Joint histograms reveal strong correlation and suggest the way FW can complement the information obtained from IWF. Combining both modalities (FW and IWF distributions) in presence of pathologies may help to define the pathophysiological basis of different disorders and identify predictors of clinical symptoms.

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