Improved 23Na MRI Quantification of the Human Brain at 3T Using Partial Volume Correction Techniques

In this study we have focused on the development and application of PVC techniques for improving the quantification accuracy of STC with 23Na MRI at 3T. Although PVEs are known to induce errors in quantification, it has not been widely used in 23Na MRI. While different PVC algorithms have been proposed in the PET literature, each method has its limitations and relies on simplified assumptions. The proposed hybrid methods, such as GTM+RBV, aimed to overcome such limitations are most robust.