In this study, we aimed to evaluate UTE-MT derived macromolecule fractions in articular cartilage subject to sequential collagenase enzymatic treatment. The preliminary result suggests that UTE-MT imaging and signal modeling allows for quantitative evaluation of macromolecular fractions in articular cartilage. Furthermore, results from UTE-MT imaging and signal modeling are insensitive to the magic angle effect, which is a huge advantage over the conventional T2 and T1rho measures. The water and macromolecular changes in both short and long T2 tissues in the knee joint using UTE-MT provides a “whole-organ” approach, and may be useful in the diagnosis and treatment of OA.
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