This study is to investigate whether adipocytes influence bone marrow microcirculation based on DCE-MRI and ex vivo high-resolution MAS 1H NMR spectroscopy. In this animal review committee-approved study, Rat Femurs were evaluated through DCE-MRI, 1H HRMAS NMRS, and histopathologic analysis before irradiation and on days 4 and 7 after irradiation. The results showed Ktrans and adipocytes gradually increased a peak on the 7th day after irradiation. In conclusion, bone marrow microcirculation permeability correlation with fat content after irradiation suggested for the first time that a pathophysiology mechanism based on fat- vascular permeability in the injury of bone marrow microcirculation.
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