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Abstract #5125

Age-related changes in healthy thigh musculature: Multi-parametric MR imaging analysis

Min A Yoon1, Suk-Joo Hong1, Chang Ho Kang2, Kyung-Sik Ahn2, Baek Hyun Kim3, and In Seong Kim4

1Department of Radiology, Korea University Guro Hospital, Seoul, Korea, Republic of, 2Department of Radiology, Korea University Anam Hospital, Seoul, Korea, Republic of, 3Korea University Ansan Hospital, Gyeonggi-do, Korea, Republic of, 4Siemens Healthcare Korea, Seoul, Korea, Republic of

Purpose: To identify MR parameters that are significantly associated with aging in healthy thigh muscles and investigate age-related characteristics.

Methods: Thirty healthy subjects underwent multi-parametric MRI of the right thigh, including IVIM-DWI, DTI, multi-echo Dixon imaging, DCE-MRI. Parametric maps of the thigh muscles (divided into three compartments) were analyzed. Relationships between parameters and age were assessed with simple and multiple linear regression analyses.

Results: Fractional anisotropy (slope=1.018) and Ve (slope=2.151) in anterior compartment and fat percentage in posterior compartment (slope=2.031) showed significant relationships to age (p<0.05).

Conclusion: Several MRI parameters of the thigh muscles were associated with normal aging.

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