A retrospective DCE-MRI of 23 patients with confirmed myeloma and 13 patients with spinal lymphoma were found. A group of 76 patients with different metastatic cancers in the spine was used as a comparison group. Three heuristic parameters: the steepest wash-in enhancement ratio, the initial area under the curve (IUAC) enhancement ratio, and the wash-out slope were measured. In the ROC analysis based on the wash-out slope, myeloma can be differentiated from lymphoma with AUC=0.913, and from mets with AUC=0.828. The wash-out slope can also differentiate lung mets from breast mets with AUC=0.812, and from thyroid mets with AUC=0.891.