Abstract #5199

Measurement of spleen fat on MRI-proton density fat fraction arises from reconstruction of noise

Cheng William Hong¹, Gavin Hamilton¹, Catherine Hooker¹, Charlie C Park¹, Calvin Andrew Tran¹, Jeffrey Schwimmer², Scott B Reeder³, and Claude B Sirlin¹

¹Liver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, CA, United States, ²Department of Pediatrics, Division of Pediatric Gastroenterology, Rady Children's Hospital, San Diego, CA, United States, ³Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin, Madison, Madison, WI, United States

Non-zero proton density fat fraction (PDFF) is commonly observed in the spleen on chemical-shift-encoded MRI. A prospective assessment in 42 research subjects with no visible fat peaks on MR spectroscopy demonstrated small amounts of splenic fat (PDFF up to 4%) using four different MRI-based fat fraction estimation techniques. These measurements were poorly correlated with each other, implying that fat measurements in spleen are likely artifactual rather than representing true splenic fat.

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