Abstract #5234

Mouse somatosensory fMRI at 9.4T using a single-shot Variable Refocusing Flip Angle 3D GRASE

Joonsung Lee¹, Hyun-Ji Shim^1,2, Hahnsung Kim³, Jungryun Lee¹, Sangwoo Kim¹, Jeong Pyo Son^1,2, Won Beum Jung^1,3, and Seong-Gi Kim^1,2,3

¹Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of, ²Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Suwon, Korea, Republic of, ³Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of

A single-shot variable flip angle (VFA) 3D GRASE imaging protocol was proposed for mouse somatosensory spin echo fMRI. Given echo-spacing of 24ms and echo train length of 8, 3D GRASE imaging parameters such as phase-encode schedule in partition direction and variable refocusing flip angles were designed to achieve pseudo-continuous signal modulation and effective TE of 40ms. BOLD fMRI experiments were performed using 9.4T MRI with ketamine anesthetized mice. For eight slice acquisition of electrical forepaw simulation fMRI, the proposed single-shot VFA 3D GRASE protocol achieved higher tSNR, t-values and larger activation areas than conventional 2D SE-EPI.

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