In this crossover intra-individual comparison study, we aimed to compare the non-ionic (godadiamide, Gd-DTPA-BMA) and ionic (gadopentetate dimeglumine, Gd-DTPA) Gadolinium based contrast agents (GBCA) in the quantitative evaluation of C6 glioma with dynamic contrast enhanced MR imaging (DCE-MRI) at 3.0 T MR scanner. Ktrans, Ve and VP maps were generated. Three radiologists independently performed tumor segmentation and value calculation. Gd-DTPA-BMA has significant more pixel counts of glioma in Ktrans map and increased tendency for average Ktrans and Kep values, indicating that DCE-MRI with Gd-DTPA-BMA may be more suitable and sensitive for the evaluation of glioma.
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