This study aimed to observe dynamic functional organization changes of large-scale resting state network (RSN) in MTLE and the patient who got seizure free after surgical treatment. Subject specific RSNs of three groups (healthy controls, presurgical group and posttreatment group) were extracted using group-information guided independent component analysis. Then, we calculated and compared the FC results between three groups, and we found FC altered markedly before and after surgical treatment. In addition, there was no statistical difference between posttreatment group and healthy controls. Our results may provide valuable information for further understanding of the pathophysiological mechanisms of intractable MTLE.