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Abstract #5285

Sense of agency is a biological function sustained by a somatosensory-premotor network

Tommaso Gili1,2, Valentina Ciullo2,3, Daniela Vecchio2,3, Gianfranco Spalletta2,4, and Federica Piras2

1Enrico Fermi Center, Rome, Italy, 2Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy, 3Psychology Department, Sapienza University, Rome, Italy, 4Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, United States

Sense of agency (SoA) refers to the experience of controlling one’s own actions. Temporal distortions between the action and the effect mislead agency attribution. We investigated the covariance between the amount of functional interactions among brain regions at rest and SoA. We found that the functional network involved in self-agency attribution included the premotor and somatosensory cortices bilaterally, and the right superior parietal lobule. This provides the first evidence that functional connectivity at rest in healthy subjects varies along with experienced SoA, implying that self-agency is processed within an intrinsic brain functional module.

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